NADPH-dependent oxidation of benzidine by rat liver
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چکیده
منابع مشابه
Oxidation ofEthanol by Isolated Rat Liver Cells
The oxidation of ethanol by isolated liver cells from starved rats is limited by the rate of removal of reducing equivalents generated in the cytosol by alcohol dehydrogenase. Evidence is presented suggesting that, in these cells, transfer of reducing equivalents from the cytosol to the mitochondria is regulated by the intracellular concentrations of the intermediates of the malate-aspartate an...
متن کاملGlyoxylic acid oxidation by rat liver.
The enzymatic formation of glyoxylate from tricarboxylic acids has focused attention on this cu-keto acid as a possible intermediate of alternate metabolic pathways (l-3). Although the isocitritase reaction has not been shown in animal tissues, recent work has indicated that the principal degradative pathway for glycine by rat liver preparations proceeds via glyoxylic acid (4). Although the oxi...
متن کاملNADPH-dependent metabolism of estrone by human liver microsomes.
We characterized the NADPH-dependent metabolism of estrone (E1) by liver microsomes of 21 male and 12 female human subjects. The structures of 11 hydroxylated or keto metabolites of E1 formed by human liver microsomes were identified by chromatographic and mass spectrometric analyses. 2-Hydroxylation of E1 was the dominant metabolic pathway with all human liver microsomes tested. E1 is more pro...
متن کاملNADPH-dependent production of oxy radicals by purified components of the rat liver mixed function oxidase system. I. Oxidation of hydroxyl radical scavenging agents.
Isolated microsomes catalyze an NADPH-dependent oxidation of typical hydroxyl radical scavenging agents. To determine which microsomal components participate in the oxidation of the scavengers, experiments were carried out with purified NADPH-cytochrome P-450 reductase and cytochrome P-450 isolated from phenobarbital-treated rats. The production of ethylene from 4-ketothiomethylbutyrate or of f...
متن کاملNADPH-dependent production of oxy radicals by purified components of the rat liver mixed function oxidase system. II. Role in microsomal oxidation of ethanol.
The oxidation of ethanol by a reconstituted system containing NADPH-cytochrome P-450 reductase and cytochrome P-450 from phenobarbital-treated rats was characterized especially with regard to the role of oxygen radicals in the mechanism of ethanol oxidation. Results described in the preceding manuscript demonstrated that a strong oxidizing species with properties similar to that of the hydroxyl...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1996
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/17.9.1941